Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes
نویسندگان
چکیده
منابع مشابه
Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice.
Bioengineered skin substitutes can facilitate wound closure in severely burned patients, but deficiencies limit their outcomes compared with native skin autografts. To identify gene programs associated with their in vivo capabilities and limitations, we extended previous gene expression profile analyses to now compare engineered skin after in vivo grafting with both in vitro maturation and norm...
متن کاملBio-Engineered Skin and Soft Tissue Substitutes
When Policy Topic is covered Breast reconstructive surgery using allogeneic acellular dermal matrix products* (i.e., AlloDerm®, AlloMaxTM, DermaMatrixTM, FlexHD®, GraftJacket®) may be considered medically necessary, when there is insufficient tissue expander or implant coverage by the pectoralis major muscle and additional coverage is required, when there is viable but compromised or thin p...
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Wound healing can be problematic in several clinical settings because of massive tissue injury (burns), wound healing deficiencies (chronic wounds), or congenital conditions and diseases. Engineered skin substitutes have been developed to address the medical need for wound coverage and tissue repair. Currently, no engineered skin substitute can replace all of the functions of intact human skin....
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Tissue-engineered skin substitutes may be either acellular or cellular. Acellular products (i.e., cadaveric human dermis with cellular material removed) contain a matrix or scaffold composed of materials such as collagen, hyaluronic acid, and fibronectin. Cellular products contain living cells such as fibroblasts and keratinocytes within a matrix. The cells contained within the matrix may be au...
متن کاملMM.06.018 Bio Engineered Skin and Soft Tissue Substitutes 070114
Bio-engineered skin and soft tissue substitutes may be either acellular or cellular. Acellular products (i.e., cadaveric human dermis with cellular material removed) contain a matrix or scaffold composed of materials such as collagen, hyaluronic acid, and fibronectin. Cellular products contain living cells such as fibroblasts and keratinocytes within a matrix. The cells contained within the mat...
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ژورنال
عنوان ژورنال: Advances in Wound Care
سال: 2012
ISSN: 2162-1918,2162-1934
DOI: 10.1089/wound.2011.0336